CORDIS Project
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This project explores how cannabinoids directly influence GABA and glycine receptors, independent of traditional cannabinoid receptor pathways. It aims to understand the implications of this interaction for neuronal activity, especially in the context of epilepsy.
Cannabinoid signaling is ubiquitous in the brain, but until now the focus has been on G-protein coupled cannabinoid receptor (CB1R) mediated effects.
Recently growing number of studies report that cannabinoids at physiologically relevant concentrations can modulate the functional properties of a number of ligand- and voltage-gated ion channels, independent of CB1R activation.
However, so far the importance of this pathway in cannabinoid signaling remains largely underestimated.
Our new findings…
UNIVERSITE DE LA MEDITERRANEE D'AIX-MARSEILLE II
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