CORDIS Project
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This project explores the development of stable derivatives of pregnenolone as potential treatments for psychotic disorders by inhibiting the cannabinoid type-1 receptor. It aims to bridge basic research with therapeutic applications to address over-activation of this receptor.
Excessive activation of the cannabinoid type-1 receptor (CB1) in the brain by synthetic, endogenous or plant-derived(cannabis sativa) cannabinoids can lead to pathological states, which could be ameliorated by blocking receptor signalling.However, due to the large number of functions involving the CB1 receptor, direct CB1 antagonist drugs induce side effectslimiting their therapeutic use.
During the ERC-StG funded project, we found that a particular endogenous and labile lipidcompound, pregnenol…
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
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