CORDIS Project
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This project investigates the role of Cyclophilin A in promoting blood vessel formation in critical limb ischemia, a condition characterized by poor blood flow. The research focuses on how this protein influences the mobilization and function of vascular progenitor cells to enhance tissue vascularization.
Critical limb ischemia (CLI) is a major health problem; it affects approximately three million people in Western Europe, its prevalence is increasing, adequate medical treatment is not available, and patients with advanced disease are usually unsuitable for revascularization procedures.
Since CLI is characterized by inadequate tissue vascularization, much effort has been focused on strategies aimed at promoting neoangiogenesis.
Emerging data suggest the clinical potential of vascular progenitor…
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