CORDIS Project

CAR T cells Rewired to prevent EXhaustion in the tumour microenvironment

CAR T-REX·101099867·HORIZON

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View on CORDIS DOI grant

Funding data

Programme: Horizon Europe
Participants: 4
Start - End: 01/04/2023 — 30/06/2027
Status: SIGNED

Summary

CAR T-REX aims to enhance the effectiveness of Chimeric Antigen Receptor T cell therapy for solid tumors by developing genetic circuits that prevent T cell exhaustion in the tumor environment. This innovative approach combines genome editing and immunology to improve cancer treatment.

Objective

Although immunotherapy of select hematological malignancies using Chimeric Antigen Receptor (CAR) redirected T lymphocytes has recently gained regulatory approval, successful treatment of solid tumors using CAR T cells remains elusive.

One salient problem is the limited efficacy and untimely exhaustion of CAR T cells in the tumor microenvironment (TME).

Combining innovative methods of genome editing, chemistry and immunology, CAR T-REX proposes to explore a novel concept of building auto-regulat…

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Coordinator

STEMMATTERS

STEMMATTERS, BIOTECNOLOGIA E MEDICIINA REGENERATIVA SA

Country: Portugal, Barco Gmr
Organization type: SME
Activity type: Private for-profit entities (excluding Higher or Secondary Education Establishments)
SME: Yes

Network and participants(4 participants)

Partner organizations (coordinator is shown above), with normalized type and CORDIS activity type. Guests see up to 4 partners.

TARGETGENE BIOTECHNOLOGIES LTD
Israel, Rehovot
Type: SME
Activity type: Private for-profit entities (excluding Higher or Secondary Education Establishments)
SME: Yes
participant
UNIVERSIDADE DE SANTIAGO DE COMPOSTELA
Spain, Santiago De Compostela
Type: University / higher education
Activity type: Higher or Secondary Education Establishments
SME: No
participant
UNIVERSITY OF DEBRECEN DE
Hungary, Debrecen
Type: University / higher education
Activity type: Higher or Secondary Education Establishments
SME: No
participant
STIFTUNG LEIBNIZ-INSTITUT FUR IMMUNTHERAPIE
Germany, Regensburg
Type: Research institute
Activity type: Research Organisations
SME: No
participant

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CORDIS call / funding scheme

Programme: HORIZON
Call: HORIZON-EIC-2022-PATHFINDEROPEN-01
Sub call: HORIZON-EIC-2022-PATHFINDEROPEN-01
Funding scheme: HORIZON-EIC
Domain note: This block describes the CORDIS project call context. Live open opportunities are managed in the Funding & Tenders domain.

Fields of Science (EuroSciVoc)

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Medical and health sciencesBasic medicineImmunologyImmunotherapy
Natural sciencesBiological sciencesGeneticsMutation

Topic

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HORIZON-EIC-2022-PATHFINDEROPEN-01-01

Keywords

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cancer immunotherapy chimeric antigen receptor (CAR) T cells solid tumours T cell exhaustion