CORDIS Project
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This project aims to develop a glycan array that mimics human airway structures to study influenza A virus binding. By identifying glycoprotein receptors, it seeks to enhance understanding of virus transmission and inform therapeutic development.
Influenza A virus has two major envelope glycoproteins:
HA and neuraminidase (NA). HA binds to sialic acid moieties of glycoconjugates of the host respiratory cells to initiate infection, whereas NA facilitates the release of progeny viruses from infected cells by cleaving sialosides.
It is well documented that binding preference is a major determinant of influenza virus host range and avian viruses preferentially bind Neu5Acα(2,3)Gal, whereas human viruses bind Neu5Acα(2,6)Gal.
This difference…
UNIVERSITEIT UTRECHT
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