CORDIS Project
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This project investigates the role of the inhibitor of F1-ATPase in the metabolism of high-density lipoprotein cholesterol and its implications for atherosclerosis. By understanding how this inhibitor affects HDL endocytosis, the research aims to identify potential therapeutic targets for preventing and treating cardio…
Several large prospective studies established that high-density lipoprotein cholesterol (HDL-C) is an independent negative risk factor for CHD thus representing today’s major protective factor against atherosclerosis, mostly attributable to their roles in ‘Reverse Cholesterol Transport (RCT)’. RCT allows excessive cell cholesterol to be taken up and processed in HDL particles, and later carried to the liver.
To identify new cellular partners involved in hepatic HDL-C clearance in human, Martinez…
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
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