CORDIS Project
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This project investigates the heart regeneration capabilities of adult zebrafish, focusing on the role of existing heart cells in the regeneration process. It aims to identify key genes involved in this process to potentially apply findings to mammalian heart regeneration.
Adult zebrafish are capable of completely regenerating their heart after an extensive insult.
Previously, we determined that the regenerated myocardium was produced by the proliferation of existing cardiomyocytes and not, as had previously been reported, by stem/progenitor cells.
Analysis of regenerating hearts shows that soon after injury cardiomyocytes detach from one another and dedifferentiate, disassembling their sarcomeric structure in the process.
In situ and microarray analysis indicate…
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
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