CORDIS Project
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This project explores the regulation of alternative splicing of the titin protein in the heart, aiming to identify therapeutic targets for diastolic dysfunction. By investigating titin's role in cardiac mechanics and developing small molecules to influence its splicing, the project seeks to improve heart function in pa…
Cardiovascular disease keeps the top spot in mortality statistics in Europe with 2 million deaths annually and although prevention and therapy have continuously been improved, the prevalence of heart failure continues to rise.
While contractile (systolic) dysfunction is readily accessible to pharmacological treatment, there is a lack of therapeutic options for reduced ventricular filling (diastolic dysfunction).
The diastolic properties of the heart are largely determined by the giant sarcomeric…
MAX DELBRUECK CENTRUM FUER MOLEKULARE MEDIZIN IN DER HELMHOLTZ-GEMEINSCHAFT (MDC)
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