CORDIS Project
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This project investigates the structure and function of dyads in cardiac myocytes, focusing on their role in calcium regulation. It employs advanced imaging techniques and genetic manipulation to understand how dyads affect heart function and disease.
Contraction and relaxation of cardiac myocytes, and thus the whole heart, are critically dependent on dyads.
These functional junctions between t-tubules, which are invaginations of the surface membrane, and the sarcoplasmic reticulum allow efficient control of calcium release into the cytosol, and also its removal.
Dyads are formed gradually during development and break down during disease.
However, the precise nature of dyadic structure is unclear, even in healthy adult cardiac myocytes, as ar…
UNIVERSITETET I OSLO
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