CORDIS Project
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This project investigates the regenerative mechanisms of the zebrafish heart following myocardial infarction. It focuses on understanding the role of myofibroblasts and specific genes in cardiac tissue regeneration, with potential implications for improving human heart health.
Myocardial infarction (MI) leading to ischemic heart disease is the most common cause of death worldwide.
In mammals, MI results in the in the replacement of the damaged myocardium with a scar.
However, other animals, such as teleost fish have a remarkable capacity to regenerate damaged tissue replacing it with newly formed tissue.
Recently, a zebrafish model of MI has been established.
Cryoinjury (CI) of 25% of the ventricle leads to massive cell death and the deposition of fibrotic tissue.
Whi…
CENTRO NACIONAL DE INVESTIGACIONES CARDIOVASCULARES CARLOS III (F.S.P.)
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