CORDIS Project
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This project focuses on developing a new chemical reaction to synthesize diketopiperazine derivatives with potential antibacterial and anticancer properties. It aims to create a biological screening unit to evaluate the efficacy of these compounds against drug-resistant bacteria and cancer.
More than 50% of drugs currently on the market are either natural product inspired derivatives or natural products.
Despite this remarkable feat, the pharmaceutical industry has partly abandoned this traditional method of drug discovery resulting in a decline of newly approved drugs.
In this context, we propose the development of a novel Pd-catalyzed cascade reaction to gain highly efficient entry into the diketopiperazine framework.
Using this newly developed chemical tool, analogs of natural p…
ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE
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