CORDIS Project
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This project investigates how the Cas9 protein from the CRISPR-Cas9 system locates its target DNA in living cells. By using advanced imaging techniques, it aims to measure the time taken for Cas9 to bind to its DNA target, providing insights into its search mechanisms and broader biological processes.
The CRISPR-Cas9 bacterial immune system has garnered intense interest both as a synthetic biology tool and as a biological system in its own right.
Yet the ability of Cas9 to find its guide-RNA-directed binding site in a timely fashion remains mysterious.
To find its binding site, the single-stranded guide RNA must recognize the appropriate homologous DNA target within double-stranded chromosomal DNA, without using ATP to melt dsDNA.
Moreover, in vitro measurements of Cas9 target search seem to…
UPPSALA UNIVERSITET
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