CORDIS Project
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This project explores the role of the Wnt-signaling pathway in cell growth and cancer. It focuses on how the protein β-catenin forms condensates that influence gene activation and aims to understand its implications for cancer development and cellular regulation.
The Wnt-signaling pathway is a key determinant of cell identity and proliferation.
However, when aberrantly activated it drives malignant cell proliferation in gastrointestinal cancer, breast cancer, melanoma and leukemia.
The key effector protein of the Wnt pathway is β-catenin, which is continuously degraded in unstimulated cells, but in stimulated cells it accumulates and translocates to the nucleus where it activates transcription. A growing body of literature indicates that transcription fa…
UNIVERSITAIR MEDISCH CENTRUM UTRECHT
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