CORDIS Project
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This project investigates the role of Caveolin1 in breast cancer metastasis and drug resistance. It aims to understand how this protein influences tumor cell behavior and to develop tools for patient stratification in chemotherapy treatments.
Breast cancer affects 1 in 8 women and is the chief cause of female cancerdeaths in the EU.
Early detection continues to improve survival, but prognosisworsens significantly after metastasis.
Metastasis and chemoresistance are linkedphenomena, but the molecular basis is unknown.
The evidence suggests a role forCaveolin1 (Cav1): i) Cav1 mediates biomechanical remodelling of the extracellularmatrix by cancer-associated fibroblasts (CAFs), promoting invasion (host labpublications); ii) Cav1 is invo…
CENTRO NACIONAL DE INVESTIGACIONES CARDIOVASCULARES CARLOS III (F.S.P.)
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