CORDIS Project
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This project explores the Sonic Hedgehog protein's role in cancer development, particularly in breast, prostate, bowel, and lung cancers. It aims to clarify the mechanisms of this critical signaling pathway to inform the design of effective cancer therapies.
With 2,6 million new cases and 1,26 million deaths in 2012, cancer is the most important cause of death in the European Union (EU).
The most common cancer forms are breast cancer, prostate cancer, bowel cancer and lung cancer.
The Hedgehog pathway is one of the most important signalling pathways in tumourigenic processes and known to be involved in all of these four types of tumours that represent 52% of all cancer cases in the EU.
Thereby, the key mediator of the signalling pathway in mammals i…
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