CORDIS Project
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This project explores the CARD9/BCL10/MALT1 signaling complex in innate immunity, which is crucial for inflammation response. It aims to understand how this complex is activated and its role in various inflammatory diseases, potentially leading to new therapeutic strategies.
Acute inflammation is a response to infection or tissue damage that is critical for host protection and tissue homeostasis.
However, deregulated or chronic inflammation is harmful to the host and can cause multiple diseases including inflammatory bowel disease, rheumatoid arthritis, cardiovascular diseases, neuroinflammatory disease and cancer.
Cells of the innate immune system sense microbial or sterile danger via pattern recognition receptors (PRRs).
Subsequently, these PRRs engage intracellul…
KLINIKUM RECHTS DER ISAR DER TECHNISCHEN UNIVERSITAT MUNCHEN
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