CORDIS Project
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This project investigates the regulation of DNA damage repair mechanisms, focusing on the interaction between the proteins CCAR2 and CtIP. By employing biochemical studies and molecular dynamics simulations, it aims to understand how these proteins influence the balance between error-prone and error-free DNA repair pat…
Ensuring cellular integrity and genome stability requires tight control of DNA damage repair.
Defects in the processes involved lead to the accumulation of mutations that might cause various diseases, including cancer. DNA double-strand break (DSB) is the most severe type of DNA damage, and two main pathways exist to repair it.
The non-homologous end joining (NHEJ) is an error-prone repair pathway with little or no DNA processing, which results in mutations of DNA sequences at the repair site. A…
UNIVERSIDAD DE SEVILLA
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