CORDIS Project
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This project investigates how cytosolic DNA sensing pathways influence the differentiation of CD4 T cells, which are crucial for adaptive immunity. The research aims to uncover the molecular mechanisms triggered by DNA that affect T cell responses to pathogens.
This proposal aims to investigate the role of cytosolic DNA sensing pathways in CD4 T cell differentiation.Cellular host defense to pathogens relies on the detection of pathogen-associated molecular patterns including deoxyribonucleic acid (DNA), which can be recognized by host myeloid cells through Toll-like receptor (TLR) 9 binding.
Recent evidence however suggests that innate immune cells can also perceive cytoplasmic DNA from infectious or autologous origin through cytosolic DNA sensors trig…
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
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