CORDIS Project
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This project examines the role of CD4 T cells in chronic inflammation, particularly in rheumatoid arthritis. It aims to identify the signals that retain these cells at inflammatory sites and explore strategies to induce tolerance in these T cells to reduce inflammation.
Inflammatory sites contain a number of different cell types that contribute to the swelling and the destruction of surrounding tissue.
In rheumatoid arthritis this inflammation occurs at joints.
The cells implicated in coordinating and amplifying this damage are CD4 T cells.
Much is known about the mediators responsible for attracting CD4 T cells into inflammatory sites.
However, the signals responsible for retaining these cells are only poorly characterised.
Understanding which key signals cont…
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