CORDIS Project
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This project investigates the molecular mechanisms of bacterial biofilm formation, focusing on the role of cyclic di-guanosine monophosphate (cdGMP) in regulating bacterial adaptation to surfaces. It aims to develop tools for modeling cdGMP dynamics in bacteria.
Bacterial biofilms are the primary cause of chronic infections and of resulting infection relapses.
To be able to interfere with bacterial persistence it is vital to understand the molecular details of biofilm formation and to define how motile planktonic cells transit into surface-grown communities.
The nucleotide second messenger cyclic di-guanosinemonophosphate (cdGMP) has emerged as a central regulatory factor governing bacterial surface adaptation and biofilm formation.
Although cdGMP signa…
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