CORDIS Project
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This project investigates how neurons develop and maintain functional networks by focusing on synapses and the axon initial segment. It aims to understand the mechanisms that stabilize neuronal excitability during significant changes in activity, which is crucial for preventing extreme network behaviors like seizures.
A critical question in neuroscience is to understand how neurons wire up to form a functional network.
During the wiring of the brain it is important to establish mechanisms that act as safeguards to control and stabilize neuronal excitability in the face of large, chronic changes in neuronal or network activity.
This is especially true for developing systems that undergo rapid and large scale forms of plasticity, which could easily lead to large imbalances in activity.
If left unchecked, they c…
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