CORDIS Project
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This project investigates the mechanisms of cell-cell fusion, focusing on the EFF-1 protein in nematodes and its relationship to viral fusogens. By analyzing crystal structures and using light microscopy, the research aims to enhance understanding of fusion processes during fertilization and organ formation.
My group has made seminal contributions in the past toward understanding the mechanism of membrane fusion used by enveloped viruses to infect a cell.
This aim of this ERC grant proposal is to achieve similar breakthroughs in understanding fusion between cells, both during fertilization and organogenesis.
This proposal is based in recent important results not yet published.We have determined the crystal structure of the C. elegans protein EFF-1, a member of the “fusion family” (FF). EFF-1 is resp…
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