CORDIS Project
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This project focuses on understanding the regulation of the myocardin family coactivators, MAL and MKL2, by actin in muscle gene expression. It employs advanced imaging techniques to track their interactions and dynamics in live cells, aiming to uncover the mechanisms behind actin's influence on transcription.
Serum response factor (SRF) regulates the expression of immediate-early genes as well as the expression of many muscle-specific genes.
Differential regulation of the expression is achieved by exclusive binding of specific coactivators. MAL and MKL2, two coactivators of the myocardin family link SRF activity to a Rho-actin signalling pathway.
Their activity is controlled through regulated interaction with G-actin, which is mediated by an RPEL domain.
Rho-activation and G-actin depletion leads to…
CANCER RESEARCH UK LBG
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