CORDIS Project
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This project aims to create a mouse model for infant pro-B acute lymphoblastic leukemia, focusing on the transformation of hematopoietic stem/progenitor cells by the MLL-AF4 oncogene. It seeks to understand the disease's origins and mechanisms by studying specific cell types during development.
Infant pro-B acute lymphoblastic leukemia (ALL) carrying the fusion oncogene MLL-AF4 is associated with very brief latency and dismal prognosis.
Recent studies have revealed an in utero origin of MLL-AF4 but the nature of the target cell for transformation in the embryo/fetus is unknown.
Because of the mixed phenotype and the presence of MLL-AF4 in both lymphoid and myeloid lineages, hematopoietic stem/progenitor cells (HSPCs) are likely targets for transformation.
The absence of bona fide disea…
FUNDACION PARA LA INVESTIGACION DEL HOSPITAL UNIVERSITARIO LA FE DE LA COMUNIDAD VALENCIANA
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INSTITUT JOSEP CARRERAS - CERCA
Spain, Badalona
Type: Research institute
Activity type: Research Organisations
SME: No
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