CORDIS Project
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This project focuses on understanding the role of Latrophilins, a type of cell-adhesion molecule, in neuronal communication. By using advanced imaging techniques, it aims to elucidate the molecular mechanisms of these receptors and their interactions, which are crucial for understanding neurodevelopmental disorders.
Synapses are intercellular junctions specialized for coordinated cell-cell communication throughout the nervous system.
They are organized by cell-adhesion molecules (CAMs) that bi-directionally orchestrate neuronal communication.
Latrophilins (LPHNs) are a unique sub-family of CAMs that play critical roles in structuring the synaptic architecture through multifaceted interactions with a large variety of synaptic partners.
Mutations in LPHN have been associated with neurodevelopmental and neurop…
WEIZMANN INSTITUTE OF SCIENCE
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