CORDIS Project
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The project investigates human naive pluripotent stem cells to enhance their potential for therapeutic applications and disease modeling. By exploring transcriptional and signaling pathways, it aims to develop safer and more effective stem cell therapies through innovative techniques and cross-species models.
An important goal of stem cell therapy is to create “customized” cells that are genetically identical to the patient, which upon transplantation can restore damaged tissues.
Such cells can be obtained by in vitro direct reprogramming of somatic cells into embryonic stem (ES)-like cells, termed induced pluripotent stem cells (iPSC).
This approach also opens possibilities for modelling human diseases in vitro.
However, major hurdles remain that restrain fulfilling conventional human iPSC/ESC poten…
WEIZMANN INSTITUTE OF SCIENCE
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