CORDIS Project
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This project develops humanized models of Alzheimer's disease using genetically engineered human stem cells. It focuses on understanding how genetic factors influence the behavior of brain cells involved in the disease, aiming to identify new drug targets for treatment.
Alzheimer disease (AD) is a major health problem worldwide.
New therapies require an accelerated translation of genetic information into mechanistic insights.
Given limitations of rodent models, fully humanized models are needed to capture the complexity of the disease process.
Human stem cells (iPS) provide great possibilities but are largely investigated in vitro with associated limitations.
Many of the novel genetic risk factors for AD are expressed in microglia and astroglia, which remains a…
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