CORDIS Project
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This project explores the lineage decisions of embryonic stem cells during early mouse development, focusing on the competition between two gene regulatory networks. By manipulating these networks, the research aims to enhance understanding of cell differentiation and developmental potential.
During early mouse embryogenesis the cells of the blastocyst’s inner cell mass take a lineage decision to contribute either to the epiblast or the primitive endoderm (PE).
The allocation of cells to either lineage depends on the activity of FGF signaling and two gene regulatory networks (GRNs), one centered on the transcription factor Nanog, the other one relying on Gata factors.
The two GRNs are initially activated in an overlapping and heterogeneous pattern in the ICM, and have been proposed t…
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