CORDIS Project
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This research develops a new technology for spatially resolved transcriptomics to study stem cell behavior in the skin and gut. By using DNA origami for precise mRNA sequencing, it aims to uncover the relationships between stem cells and differentiated cells in their native environments.
The research I propose here will provide an enabling technology; spatially resolved transcriptomics, to address important problems in cell- and developmental-biology, in particular:
How are stem cells in the skin and gut proliferating without turning into cancers?
How are differentiated cells related, in their transcriptome and spatial positions, to their progenitors?To investigate these problems on a molecular level and open up paths to find completely new spatiotemporal interdependencies in co…
KAROLINSKA INSTITUTET
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