CORDIS Project
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This project explores the role of amyloid intermediates in neurodegenerative disorders like Parkinson's disease. By identifying cellular factors associated with these intermediates, it aims to understand their neurotoxic effects and provide insights for potential therapeutic targets.
Neurodegenerative disorders such as Alzehimer´s or Parkinson´s affect millions of people in Europe and are linked to the misfolding and aggregation of proteins in the form of amyloid fibrils.
The molecular pathways of amyloid aggregation are complex and poorly understood, and involve the population of oligomeric intermediates before fibrils form.
Little is known about the role in vivo of amyloid intermediates, despite generally recognized as the major neurotoxic agents.
The challenge of this pro…
FUNDACIO INSTITUT DE RECERCA BIOMEDICA (IRB BARCELONA)
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