CORDIS Project
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This research focuses on understanding the assembly and budding processes of the respiratory syncytial virus, a major cause of respiratory illness. By identifying the viral proteins involved, the project aims to develop new antiviral strategies and potential vaccines against this significant health threat.
Respiratory syncytial virus (RSV) is the leading cause of bronchiolitis and pneumonia in infants and the elderly worldwide.
Despite that, there is no licensed RSV vaccine and only limited therapeutics exists. RSV primarily infects epithelial cells of the respiratory tract and replicates in the cytoplasm.
Viral proteins traffic to the apical cell surface where they assemble into virus filaments and bud.
However, the mechanism of virus filament formation and budding is poorly understood, neither i…
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