CORDIS Project
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This project explores the concept of synthetic viability in the context of DNA-damage response mechanisms, aiming to identify gene interactions that could lead to new cancer treatments and insights into genetic diseases.
Various human genetic diseases are caused by defects in the DNA-damage response (DDR). DDR genes protect against cancer, as demonstrated by their somatic mutation or epigenetic silencing being common in cancers.
Cancer-specific DDR deregulation is ripe for therapeutic exploitation but clinicians are facing two main problems: accurate identification of such exploitable cancer cell defects and development of resistance mechanisms that render tumours unresponsive to classical or targeted chemothera…
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