CORDIS Project
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This project investigates the organization and dynamics of microtubules in neurons to understand how their structure influences intracellular transport. By employing advanced microscopy and mathematical modeling, it aims to create a comprehensive 3D map of dendritic microtubules and explore their role in cellular logis…
The organization and dynamics of the MT (MT) cytoskeleton underlies the morphology, polarization and division of most cells.
The structural polarity of MT determines the directionality of motor proteins, which move selectively towards either the MT plus (most kinesins) or minus end (dynein) to control the transport and positioning of proteins and organelles.
Understanding how different cellular MT arrays, such as the mitotic spindle or neuronal MT networks, are built and utilized to ensure prope…
UNIVERSITEIT UTRECHT
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