CORDIS Project
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This project aims to understand the molecular mechanisms of protein quality control and its role in preventing neurodegenerative diseases. By studying E3 ubiquitin ligases, the research seeks to uncover how cells manage damaged proteins under stress.
Maintaining the quality of all proteins in an organism is fundamental to life since it ensures tissue function, organismal health, and longevity.
Protein quality control (PQC) is achieved by selective degradation of damaged proteins, limiting the formation of protein aggregates and neurodegeneration characteristic of Alzheimers, Huntingtons, and Parkinsons disorders.
Important regulators of cellular proteolysis are E3 ubiquitin ligases that target damaged proteins for degradation.
However, thera…
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