CORDIS Project
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This research investigates the role of the histone variant CenH3 in chromosome segregation across various insect lineages. It aims to characterize a unique pathway of kinetochore assembly that allows for chromosome segregation without CenH3, revealing evolutionary adaptations in holocentric insects.
Faithful chromosome segregation in all eukaryotes relies on centromeres, the chromosomal sites that recruit kinetochore proteins and mediate spindle attachment during cell division.
Fundamental to centromere function is a histone H3 variant, CenH3, that initiates kinetochore assembly on centromeric DNA.
CenH3 is conserved throughout most eukaryotes; its deletion is lethal in all organisms tested.
These findings established the paradigm that CenH3 is an absolute requirement for centromere functio…
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