CORDIS Project
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This project focuses on understanding and engineering the assembly of centrioles, essential cellular structures involved in cell division and signaling. It employs advanced techniques to dissect the dynamics of centriole formation and the roles of various proteins in this process.
Deciphering and engineering the assembly of cellular organelles is a key pursuit in biology.
The centriole is an evolutionarily conserved organelle well suited for this goal, and which is crucial for cell signaling, motility and division.
The centriole exhibits a striking 9-fold radial symmetry of microtubules around a likewise symmetrical cartwheel containing stacked ring-bearing structures.
Components essential for generating this remarkable architecture from alga to man have been identified.…
ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE
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