CORDIS Project
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This research focuses on the assembly and maturation of centromeres during the cell cycle, specifically the role of Centromere Protein A in epigenetic inheritance. The study aims to understand the mechanisms that prepare centromeric chromatin for kinetochore assembly.
Two essential phases exist in centromere assembly and maturation during the cell cycle; a G1 phase in which CENP-A is replenished to establish replication competent centromeres and a late-S/G2 phase, in which additional assembly events establish a centromeric substrate competent for kinetochore assembly.
The centromere provides a unique context in which to examine the question of epigenetic inheritance.
Centromere protein A (CENP-A) is a conserved histone H3 variant that replaces canonical H3 sp…
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