CORDIS Project
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This project investigates how centrioles, essential for cell structures, are eliminated during the development of the C. elegans organism. It employs advanced imaging and sequencing techniques to explore the molecular mechanisms of centriole elimination, with a focus on the RNA-binding protein CGH-1 and evolutionary co…
Centrioles are evolutionary conserved organelles that template the formation of cilia, flagella and centrosomes.
Centriole number dictates how many such structures form in a cell, so that controlling this number is essential for proper development and health.
During sexual reproduction of animals, only the sperm contributes centrioles to the zygote, whereas centrioles are eliminated from the oocyte.
The signals initiating and the processes executing centriole elimination remain largely elusive,…
ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE
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