CORDIS Project
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This research focuses on understanding the role of centrosome amplification in pediatric Acute Lymphoblastic Leukaemia. It aims to develop new diagnostic methods and therapeutic strategies by analyzing chromosomal instability in cancer cells.
Paediatric Acute Lymphoblastic Leukaemia (pALL) still accounts for most cancer-related deaths in children.
Although high hyperdiploidy (HHD) is the most frequent pattern, its pathomechanism remains poorly understood.
Recently, Experienced Researcher (ER) et al showed that sequential chromosomal gains and chromosomal instability (CIN) are critical features in HHD-pALL evolvement.
The most common cause of CIN is centrosome amplification (CA) and recent findings indicate that inhibiting centrosome…
DEUTSCHES KREBSFORSCHUNGSZENTRUM HEIDELBERG
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