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CentRed investigates the role of the sperm centrosome in early embryo development, focusing on its structural changes during sperm formation. The project aims to understand how defects in this organelle contribute to unexplained infertility, potentially leading to new diagnostic and treatment approaches.
Worldwide, 17% of couples are affected by infertility, with studies showing a steady decline in sperm quality over recent decades.
One in three cases remain unexplained, often marked by a sudden loss of the early embryo due to erroneous cell division, and are therefore hard to treat.
Case studies link early embryonic loss to defects in the sperm centrosome, a paternally inherited organelle essential for the embryo's first cell division.
Unfortunately, a mechanistic understanding of sperm centros…
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