CORDIS Project
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The project aims to understand centriole biogenesis, particularly the elongation process, by identifying molecular regulators involved. Using RNA interference and mass spectrometry, it seeks to uncover new players in centriole length control through both mammalian and Drosophila models.
Centrioles are cellular organelles made of microtubules that are essential for centrosome, cilia and flagella assembly and as such are involved in a variety of cellular and developmental processes, including cell motility, division and polarity.
Centriole biogenesis is first seen during S phase by the appearance of procentrioles that elongate as the cell cycle progresses to reach nearly full length in mitosis.
Most mature centrioles in an organism have similar length, yet very little is known on…
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