CORDIS Project
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The CERIPA project focuses on developing sustainable methods to modify antifungal compounds, specifically polyenes, to enhance their effectiveness and reduce toxicity. By utilizing innovative enzymatic techniques, the project aims to create new derivatives that are more soluble and less harmful, addressing the urgent n…
Fungal infections are an increasingly serious global health threat, driven by rising antimicrobial resistance (AMR) and a critical lack of new antifungal drugs in development.
Currently, treatment relies heavily on Amphotericin B (AmB) and a small group of related polyene natural products.
However, the clinical use of these compounds is limited by their poor solubility and significant toxicity.
Research has shown that chemical modifications of polyenes like AmB can reduce their toxicity, but tra…
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