CORDIS Project
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This project explores the role of ceramide synthases in pancreatic beta cells and their impact on diabetes development. By combining various scientific techniques, it aims to identify and target specific enzymes that could improve insulin secretion and reduce beta cell stress.
Sphingolipids including ceramides are building blocks of cell membranes, but also act as regulated intracellular messenger molecules.
Emerging data indicate that sphingolipids are dynamically regulated by nutrients, and in turn control systemic metabolism, for example, by modulating insulin secretion, proliferation and cell death of pancreatic beta cells.
Dysfunction and death of beta cells are key events during the development of diabetes, from which more than 400 million patients suffer worldw…
DEUTSCHE DIABETES FORSCHUNGSGESELLSCHAFT EV
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