CORDIS Project
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This project investigates the clonal evolution of cancer cells, focusing on Fanconi anemia and T-cell acute lymphoblastic leukemia. It aims to identify key pathways in leukemia progression and develop new strategies for monitoring and treating patients to improve outcomes and reduce relapse rates.
Clonal evolution represents a driving force for cancer cells and a major challenge for therapy.
There is a long-standing knowledge that clonal diversification and selection allows cancer cells to pass through distinct steps of transformation.
More recently has emerged the concept that ""more malignant"" leukemia subclones can persist after treatment leading to relapse.
My research is focused on two diseases which represent privileged models to study clonal evolution:
Fanconi anemia (FA), which i…
Université Paris Diderot-Paris 7
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