CORDIS Project
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This project aims to develop a new method for modifying aromatic compounds using photocatalysis to create CF3-diazomethylated drugs. It focuses on synthesizing new antibiotics and improving imaging techniques for medical applications, particularly in positron emission tomography.
The main goal of this Marie Skłodowska-Curie (MSC) application is to develop a new photocatalytic C–H bond CF3-diazomethylation of aromatic rings with a new class of hypervalent iodine reagents.
Our approach is enabled by the photocatalytic generation of a previously elusive electrophilic carbyne radical, which is able to induce C-H bond cleavage.
Preliminary results suggest that the proposed transformation will be able to functionalize complex drug molecules and provide valuable CF3-diazomethyl…
FUNDACION PRIVADA INSITUTO CATALAN DE INVESTIGACION QUIMICA ICIQ
FUNDACIO PRIVADA INSTITUT CATALA D'INVESTIGACIO QUIMICA
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