CORDIS Project
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This project investigates the roles and mechanisms of cohesin in chromosome biology using the fruit fly Drosophila melanogaster. It focuses on cohesin's functions in cell division, DNA repair, and gene regulation, particularly in the context of cancer and age-related infertility.
Cohesin has numerous fundamental roles in eukaryotic chromosome biology.
It promotes sister chromatid cohesion during cell division and is therefore essential for faithful duplication and segregation of genomic information, a fundamental processes for life.
In addition to its canonical role in holding sister chromatids together during mitosis and meiosis, cohesin plays a role in the repair of double strand breaks and in regulating transcription.
These are key processes that are often malfunction…
THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
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