CORDIS Project
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The CHAMELEO project aims to understand how low oxygen levels in cancer affect DNA methylation and gene expression. It focuses on the role of specific enzymes in regulating these processes and their implications for tumor suppressor genes and cancer progression.
DNA methylation is integral to the regulation of gene transcription but is deregulated in cancer.
Mechanisms causing this dysregulation are however poorly understood.
Although DNA methylation mechanisms were described for several decades ago, the enzymes responsible for DNA demethylation were only discovered a few years ago:
TET enzymes catalyze the conversion of 5-methylcytosine to 5-hydroxymethylcytosine (5hmC) through a reaction requiring oxygen and 2-oxoglutarate (2OG).
Interestingly, decrea…
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