CORDIS Project
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This project explores the use of C–H acids in asymmetric synthesis to improve enantioselective organocatalysis. By developing new catalysts, it aims to expand the range of substrates that can be effectively used in these reactions, addressing existing limitations in the field.
Enantioselective Brønsted acid organocatalysis has the potential to revolutionize asymmetric synthesis.
However, the commonly used chiral phosphoric acid catalysts are typically limited to certain, fairly reactive substrate classes such as imines.
Recently, more active and stereoselective catalysts have been introduced, which rely on acidic N–H bonds, and which have significantly widened the scope of suitable substrates.
Despite the considerable success of these catalysts, however, several impor…
MAX PLANCK INSTITUT FUER KOHLENFORSCHUNG
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