CORDIS Project
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This project investigates the assembly and function of respiratory complexes in bacteria, focusing on the role of a newly identified chaperone in iron-sulfur cluster biogenesis. Advanced imaging techniques will be developed to study these interactions within the cellular environment.
Cellular respiration provides energy to power essential processes of life.
Respiratory complexes are macromolecular batteries coupling electron flow through a wire of metal clusters and cofactors with proton transfer across the inner membrane of mitochondria and bacteria.
Waste products of these cellular factories are reactive oxygen species causing ageing and diseases.
Assembly and maturation mechanisms of respiratory complexes remain enigmatic because of their membrane location, multisubunit…
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
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