CORDIS Project
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This project investigates how molecular chaperones, which assist in protein folding, are regulated in different cell types, particularly neurons. By understanding these mechanisms, the research aims to provide insights into the susceptibility of certain tissues to protein misfolding diseases.
Protein misfolding causes devastating health conditions such as neurodegeneration.
Although the disease-causing protein is widely expressed, its misfolding occurs only in certain cell-types such as neurons.
What governs the susceptibility of some tissues to misfolding is a fundamental question with biomedical relevance.
Molecular chaperones help cellular proteins fold into their native conformation.
Despite the generality of their function, chaperones are differentially expressed across various…
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